I use chrome to develop websites because of its built-in development tools, then once ready check it on the major browsers like Firefox $LATEST_VERSION and IE8 (if I know customer still uses XP) or just IE9. The fact Opera has no JS and HTML rendering implementation of its own means I can leave Opera out of my routine altogether, which is what I am pleased about.
I do not care one bit if things are not exactly laid out as I intended. This is not the sort of thing that matters. The site just has to be usable and controls laid out approximately where I intended them to be placed originally. If something isn't quite where I intended but the site is usable, I'll just state that it's a browser issue that likely fixes itself in some future update.
The layout issues that are too severe to be ignorable, I circumvent with IE8/IE9 targeted conditional comments and Firefox-specific CSS workarounds. Most of the time I only need some simple hacks for IE8, as all the other browsers (including Opera) tend to render everything pretty much the same way.
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