Overall, I am more concerned about things that seem to openly not to want to run under Wine. I think you can count iTunes as an example. As people move more and more to web-based things instead of local applications we Linux and FreeBSD folks have it easier. However, iTunes and a few similar things stand out as a new generation of "killer applications" that you need. As it is you have to gear up VMware for it.
I understand that Amazon's kindle for PC (Windows) runs under Wine, but do I really want to invest money in electronic books on Amazon when the reader might become broken under Wine any day?
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