I've been running my machines at home with SELinux enabled for years. I've occasionally had a problem, but overall it's gone rather smoothly. About a year ago I needed to disable SELinux for about a day until the Fedora folks fixed a problem. I've learned enough about how the labels work that I can fix simple issues.
It doesn't prevent you from putting your car in gear.
And it's still easy to turn off from the command line. Users who are going to stick to the GUI can run with the policies Fedora ships, and they work.
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