You might also want to try Kanotix. It's based on Debian/Knoppix with some tweaks added, and while Knoppix is mainly focused on being a livecd, Kanotix is usually intended for eventual hard drive install. While I liked Mepis a lot, Kanotix has been a better fit for my laptop (Toshiba A75) - video is working, sound, dvds play fine, touchpad works, wireless (atheros/madwifi), etc. You didn't say what computer you had, but if it's a laptop and you're having trouble finding a distro where everything just works, I'd try Kanotix.
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