LyX

I have used, and continue to use, LyX when writing papers for publication [biochemistry/computational biology]. I have never had a problem with it crashing. The biggest problem has been deciding "is it worth the time to write a LyX template to match the LaTeX template this journal will accept for submission?". It has been a pleasant surprise going back 20 years or so how many biology journals are willing to accept submissions in LaTeX, even though it may require bypassing the default final-stage submission process and corresponding directly with the print office rather than the editorial office.