I've seen this and used it; even just using something as simple as a MoinMoin wiki page for the content.
I've seen presentations by Twiki's creator and he uses Twiki for his presentation backend (there are even plug-ins for this purpose) and Mozilla (if I recall correctly) for the front end.
I would use these only for the most informal presentations, but it is quick and the issue of publishing the slides unto the web is inherently handled.
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