I use GNOME 3 on a 27" 2560x1440 monitor, and I've had no issues. The side-by-side half-maximize feature helps greatly with organizing windows.
I suspect preferences for using maximized windows make a bigger difference. I always run with either a single maximized window or with two windows maximized side-by-side; either way, the title bar(s) and the gnome-shell bar are right next to each other. Similarly, I don't use workspaces at all, because when all your windows are maximized, switching between windows (via alt-tab or the overview) is the equivalent of switching between workspaces.