I am not saying that it will run the desktop inside a VM, but I aldo don't see touchscreen software being run on a 30" non-touchscreen monitor well.
If you have a Linux base, there's nothing (conceptually) preventing you from running libreoffice and thunderbird when docked, but then suspend/checkpoint that software when you undock, using touch-friendly Android apps on the small screen. You may have some 'mobile' apps running in small windows on your big screen (no need to have two weather apps for example)
Yes, right now Android and Linux have completely different userspace libraries, but are they really that different in their functionality and API? or could you have one libc that will work for both?
I'm a bit puzzled that nobody has created the ability to run android apps on a full Linux box yet (I think we're getting very close on the kernel capabilities side, but Android hasn't taken advantage of all the recent mainstream developments yet).
Once you have the ability to access the android app store and run regular Linux apps, I expect that something like the Transformer phone/laptop will start to appear, with normal Linux apps when docked and limited to android apps when undocked.
I don't expect such things to first show up from the "big boys", they will be trying to do the all singing all dancing single solution to everything. Instead I expect that some of the low-end "knock-off" companies will throw something like this together and start selling it with it working well enough that others will then jump on the bandwagon