| |||||||||||||
Most patents are drag on the innovationMost patents are drag on the innovationPosted Feb 9, 2012 22:46 UTC (Thu) by Cyberax (✭ supporter ✭, #52523)In reply to: Most patents are drag on the innovation by Wol Parent article: Mueller: Apple's iterative approach to FRAND abuse is not for the faint of heart
No, thalidomide is racemic - it spontaneously flips between L- and R- forms.
However, it's a great and simple example of reasons beyond the extensive drug testing which begins with the toxicity tests, and with the compound which will later be certified and sold.
(Log in to post comments)
Most patents are drag on the innovation Posted Feb 10, 2012 13:23 UTC (Fri) by Wol (guest, #4433) [Link]
Exept that's not what "racemic" means. All racemic means is "50/50 L and R", not "L and R spontaneously flip". Actually, that flip is pretty much impossible without something there to catalyse the reaction.
But it's normal to get a pure L or R isomer or a racemic mix, depending how you produce it. And it's quite likely, similar to what you assert, that when they produced commercial quantities one of the production steps contained a catalyst that converted from "all L" to "racemic mix". Which they wouldn't have picked up unless they were actively looking for it.
Cheers,
Most patents are drag on the innovation Posted Feb 10, 2012 13:41 UTC (Fri) by Cyberax (✭ supporter ✭, #52523) [Link]
>Exept that's not what "racemic" means. All racemic means is "50/50 L and R", not "L and R spontaneously flip". Actually, that flip is pretty much impossible without something there to catalyse the reaction.
Well, it does interconvert at least in-vivo: http://www.ncbi.nlm.nih.gov/pubmed/15080764
Most patents are drag on the innovation Posted Feb 13, 2012 11:54 UTC (Mon) by nye (guest, #51576) [Link]
>Exept that's not what "racemic" means. All racemic means is "50/50 L and R", not "L and R spontaneously flip". Actually, that flip is pretty much impossible without something there to catalyse the reaction.
Thalidomide will racemize in the body. From http://www.ncbi.nlm.nih.gov/pubmed/15080764: "Thalidomide interconverts between the (R)- and (S)-enantiomers in plasma"
I think it's quite common for enantiomers to flip. For example, get some fresh caraway, and note that it smells *very slightly* like spearmint. Then leave it in a jar for a year or two, and note that it now smells rather *strongly* of spearmint as some of the s-carvone has become r-carvone.
Most patents are drag on the innovation Posted Feb 13, 2012 11:55 UTC (Mon) by nye (guest, #51576) [Link]
And now I notice somebody else has posted the same link. That's what I get for not refreshing the page after the weekend.
|
|||||||||||||