I have mandatory OCSP in my Firefox. Since I enabled it I had some hiccups here and there but nothing too important. I have, however, experienced a quite interesting situation:
Commercial Wi-Fi hotspots usually redirect your traffic to their own website where you can buy a short-term pass or a subscription.
Since a) those WiFi networks are non-encrypted, b) they require either a short code that's equivalent to some money paid or your credit card, it's frequent to see HTTPS being used on their captive portal.
But the hotspot doesn't allow any kind of traffic besides connecting to the captive portal and even redirects HTTP requests that try to connect elswhere.
which breaks OCSP. And present you with a nice chicken-and-egg problem.
(yes, they're broken by design, and yes I know about iodine :))