Cedega seems to be pretty much dead anyway. You might speculate that this is what not cooperating got them. Apart from new releases petering out they have also broken the few things that older Cedega releases did for me that Wine did not.
Overall, I am more concerned about things that seem to openly not to want to run under Wine. I think you can count iTunes as an example. As people move more and more to web-based things instead of local applications we Linux and FreeBSD folks have it easier. However, iTunes and a few similar things stand out as a new generation of "killer applications" that you need. As it is you have to gear up VMware for it.
I understand that Amazon's kindle for PC (Windows) runs under Wine, but do I really want to invest money in electronic books on Amazon when the reader might become broken under Wine any day?