I've yet to see someone developing a significantly used package management system (Eg. rpm/dpkg/yum/apt/zypp/smart/etc.) that thinks autopackage, Nix or zero-install is going to work.
Dito. for anyone in rel-eng at a large distribution (Eg. Debian, Fedora, OpenSuSE, Ubuntu, etc.)
I've yet to see autopackage, Nix or zero-install distribute a significant number of used packages ... and thus. show that they can work at anything above toy examples.
Feel free to get back to me when one of the above is true.