Depends on what you call "real work". Is desktop use real work? Fedora is my preferred distro for desktop usage because I like the bleeding edge stuff, don't mind the constant stream of updates, and don't mind occasional (almost always only minor) breakage. Makes me check bugzilla more often and contribute. :)
I don't often run Fedora on servers (or server virtual machines / containers) unless I have a need for something newer than RHEL5/CentOS5 and that isn't very often.