We manage alright. We have a fairly complicated application that uses Qt and about a dozen other
third party libraries. Our binaries (http://www.hyves.nl/hyvesdesktop/download/) have been
reported to work successfully on many linux distributions.
Of course, we ran into trouble when we wanted to support sound. Qt's phonon uses GStreamer as a
backend and that's a mess. We came to the conclusion that we'd better use QSound, since the
alternative would have been to redistribute the right gstreamer with all plugins ourselves.
Something compiled against a platfrom gstreamer on one distribution will crash on all other
distributions (that we tried).