I have a Huawei 169 3G stick, and a recent update in F10 broke it. It was interesting to read the article and see what NM has to do with this type of hardware; to be honest, I've lost basically all my pppd knowledge and without a GUI I would be pretty much at sea unless I was going to re-learn all that stuff again (which, frankly, I don't want to do).
Dan's update to F10 today fixes the problem for me, and I'm in "just works" land again, thank goodness. Plug in stick, NM kicks it, I'm online.
I would go as far as to say NM is better than any other system I've seen on any platform; it simply rocks. It doesn't always work, it has rough edges, it's not perfect for the static IP crowd yet. But my goodness, it's pretty darn keen.