I suspect you're running an ancient version of GNOME and GTK+. On a Fedora 9 system browsing
/usr/bin from "Open with..." seems snappy to me even on a low end laptop. Most likely the
file magic problem you're describing got fixed some time ago. Furthermore your point about
GNOME is similarly outdated because the file browser is part of GTK+ itself these days. So
it's standard for all GTK+ applications.
Breaking printing for all users would indeed be a catastrophe (or at least it would in a final
release, which hasn't happened). But that isn't the case here. So far all we've established
is that printing is broken for one user with an unusual configuration. That's unfortunate and
certainly a stumbling block -- for you -- but it's not a major regression from the perspective
of the Firefox team and certainly doesn't indicate that the project is moving in the wrong
direction.
To argue otherwise is to expose an inflated sense of your own importance.